Abstract Search

ea0081ep355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Distinct inflammatory signatures of upper- and lower-body adipose tissue in postmenopausal women with normal weight and obesity

Lempesis Ioannis , Hoebers Nicole , Essers Yvonne , Jocken Johan WE , Blaak Ellen E , Manolopoulos Konstantinos N , Goossens Gijs H

Background: Abdominal obesity is associated with insulin resistance and increased cardiometabolic disease risk, whereas lower-body fat accumulation seems protective against metabolic derangements. Differences in upper-body and lower-body adipose tissue (AT) function seem to underlie these opposing associations. Here, we investigated the inflammatory signature of upper- and lower-body AT in women with normal weight and obesity, as well as in human primary abdominal (ABD) and fe...

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ea0059cc6 | Featured Clinical Cases | SFEBES2018

What lies beneath: cutaneous Kaposi’s sarcoma as a first manifestation of ectopic ACTH-dependent Cushing’s syndrome

Tresoldi Alberto S , Elhassan Yasir S , Asia Miriam , Elshafie Mona , Lane Peter , Manolopoulos Konstantinos N , Velangi Shireen S , Watkins Steven , Arlt Wiebke , O'Reilly Michael W

Introduction: Immune dysregulation is a feature of Cushings syndrome (CS). We report a case of CS that presented with rapidly developing cutaneous Kaposis sarcoma (KS).Case description: A previously well 59-year-old heterosexual man presented with a two-month history of proximal muscle weakness, recurrent mouth ulcers, and purplish skin lesions. He had a background history of hypertension. Skin biopsies were compatible with KS. History of pas...

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ePoster

ea0073pep11.6 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Increased risk of cardiometabolic disease in patients with benign adrenal tumours with and without cortisol excess: a case–control study

Prete Alessandro , Subramanian Anuradhaa , Bancos Irina , Sitch Alice J , Chortis Vasileios , Lang Katharina , Tsagarakis Stylianos , Macech Magdalena , Delivanis Danae A , O’Reilly Michael W , Masjkur Jimmy R , Quinkler Marcus , Ueland Grethe Å , Dennedy M Conall , Beuschlein Felix , Tabarin Antoine , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Kastelan Darko , Young William F Jr , Manolopoulos Konstantinos N , Ambroziak Urszula , Vassiliadi Dimitra A , Nirantharakumar Krishnarajah , Arlt Wiebke

BackgroundBenign adrenocortical tumours are found in 35% of adults and can be non-functioning (NFAT) or associated with cortisol excess. The latter group divides into patients with clinically overt signs (adrenal Cushings syndrome, CS) and patients lacking CS signs (mild autonomous cortisol excess, MACE). The 1 mg-overnight dexamethasone suppression test (DST) further differentiates MACE into MACE-1 (possible MACE; post-DST cortisol 501...

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ea0075r03 | Reproductive Endocrinology | EYES2021

PCOS SEVa: High prevalence of anxiety, depression and body dysmorphia in people with PCOS suggesting we need to rethink how we screen and manage emotional wellbeing in people with PCOS

Hebbar Meghnaa , Zia Nawal , Sheikh Jameela , Wicks Saskia , Jayaprakash Sindoora , Narendran Alisha , Khalil Halimah , Melson Eka , Busby Maureen , Tahrani Abd A. , Hillman Sarah , Chapman Rachel , Gleeson Helena , Singh Ruchira , Robinson Lynne , Manolopoulos Konstantinos N. , Gillett Caroline D.T. , Thangaratinam Shakila , Arlt Wiebke , Kempegowda Punith

Aim: We evaluated the emotional wellbeing and lifestyle advice received by people with PCOS in comparison to National Institute of Health and Care Excellence (NICE) and international guidelines. Methods: Patients attending fertility clinics at Queen Elizabeth Hospital Birmingham between October 2020-May 2021 and in India between March 2021-May 2021 were invited to complete surveys before and after attending clinic. Pre-clinic survey had questions on demographics, Hospital Anxi...

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ea0077ec1.2 | Early Career Prize Lecture Basic Science (1) | SFEBES2021

Cardiometabolic disease burden and urine steroid metabolome in benign adrenocortical tumours: a case-control study

Prete Alessandro , Subramanian Anuradhaa , Bancos Irina , Chortis Vasileios , Tsagarakis Stylianos , Lang Katharina , Macech Magdalena , Delivanis Danae A , Pupovac Ivana D , Reimondo Giuseppe , Marina Ljiljana V , Deutschbein Timo , Balomenaki Maria , O’Reilly Michael W , Bednarczuk Tomasz , Zhang Catherine , Dusek Tina , Diamantopoulos Aristidis , Asia Miriam , Kondracka Agnieszka , Li Dingfeng , Masjkur Jimmy R , Quinkler Marcus , Ueland Grethe AE , Dennedy M Conall , Beuschlein Felix , Tabarin Antoine , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Kastelan Darko , Young Jr William F , Manolopoulos Konstantinos N , Ambroziak Urszula , Vassiliadi Dimitra A , Taylor Angela E , Sitch Alice J , Nirantharakumar Krishnarajah , Arlt Wiebke

Background: The overwhelming majority of incidentally discovered adrenal tumours are benign adrenocortical adenomas. These can be non-functioning (NFAT) or associated with cortisol excess on a spectrum ranging from rare clinically overt adrenal Cushings syndrome (CS) to much more prevalent mild autonomous cortisol secretion (MACS) without signs of CS. The 1mg-overnight dexamethasone suppression test (DST) further differentiates MACS-1 (possible MACS; post-DST cortisol 50...

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Endocrine Abstracts

Distinct inflammatory signatures of upper- and lower-body adipose tissue in postmenopausal women with normal weight and obesity

What lies beneath: cutaneous Kaposi’s sarcoma as a first manifestation of ectopic ACTH-dependent Cushing’s syndrome

Increased risk of cardiometabolic disease in patients with benign adrenal tumours with and without cortisol excess: a case–control study

PCOS SEVa: High prevalence of anxiety, depression and body dysmorphia in people with PCOS suggesting we need to rethink how we screen and manage emotional wellbeing in people with PCOS

Cardiometabolic disease burden and urine steroid metabolome in benign adrenocortical tumours: a case-control study

BiosciAbstracts